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Spider-Man 2099
Miguel O'Hara is a brilliant Irish-Mexican geneticist living in Nueva York (a renamed New York City) in the year 2099. He attempts to re-create the abilities of the original Spider-Man in other people and later suffers a related accident that causes half of his DNA to be rewritten with a spider's genetic code. This gives him the powers of Spider-Man, including super strength, speed, and agility, as well as the ability to shoot webs from his wrists.
O'Hara uses his powers to fight crime in Nueva York and protect the innocent. He has also appeared in numerous other media adaptations, including the animated film Spider-Man: Into the Spider-Verse (2018), where he was voiced by Oscar Isaac.